胰岛素受体底物-1(insulin receptor substrate-1, IRS-1)作为多位点的锚定蛋白，连接受体激酶和信号蛋白质，引起受胰岛素调节的许多细胞内的多种功能的活化。

• Insulin receptor substrate-1 (IRS-1) acts as a multisite docking protein that binds signal proteins and links the receptor kinase to a number of cellular functions that are regulated by insulin.